PfizerFlex Patient Support Program for IXIFI® – Rheumatoid Arthritis

About rheumatoid arthritis

Rheumatoid arthritis is a disease in which the immune system mistakenly attacks and damages healthy tissue in the joints. This leads to inflammation (swelling) in these tissues which can cause pain. This damage can eventually lead to other parts of the body. Rheumatoid arthritis is more common in women.

What is IXIFI used for?

IXIFI is a medicine that is used in people with moderate to severe rheumatoid arthritis (in combination with methotrexate).

How does IXIFI work?

Research has shown that in rheumatoid arthritis, the body overproduces a substance known as tumour necrosis factor alpha (TNF alpha). The active ingredient in IXIFI is called infliximab. Infliximab is a monoclonal antibody, a type of protein that recognizes and binds to other unique proteins. Infliximab binds to and neutralizes TNF alpha. Infliximab is made from mouse and human proteins.

IXIFI is a medicine that affects your immune system. IXIFI can lower the ability of your immune system to fight infections.

Usual dose

IXIFI will be given to you by a healthcare professional. The medicine will be given to you through a needle placed in a vein in your arm. This is called an infusion. The first 3 infusions will be given to you over a period of about 2 hours. After the third infusion, your doctor may decide to give you the infusion over a 1 hour period.

During the infusion you will be monitored for side effects. You must stay for 1 to 2 hours after the infusion so that you can continue to be watched for any reactions to the medicine.

The recommended dose of IXIFI is 3 mg/kg. IXIFI should be given in combination with methotrexate.

Infusion 1

Infusion 2

Infusion 3

Every 8 weeks thereafter for all following infusion

Please refer to your patient leaflet for complete dosing instructions.

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