PfizerFlex Patient Support Program for IXIFI® – Ulcerative Colitis

About ulcerative colitis

Ulcerative colitis is a long-term condition causing inflammation and ulcers in the lining of the large intestine (colon), most commonly the last part of the colon and the rectum. Symptoms can flare up and then disappear (called remission).

Ulcerative colitis can start at any age but is most likely to develop in people between the ages of 15 and 45.

What is IXIFI used for?

IXIFI is used in adults, children and teenagers with moderate to severe ulcerative colitis. Your doctor has chosen to treat your ulcerative colitis with IXIFI because your disease is still active even though you have tried other treatments.

How does IXIFI work?

Research has shown that in ulcerative colitis, the body overproduces a substance known as tumour necrosis factor alpha (TNF alpha). The active ingredient in IXIFI is called infliximab. Infliximab is a monoclonal antibody, a type of protein that recognizes and binds to other unique proteins. Infliximab binds to and neutralizes TNF alpha. Infliximab is made from mouse and human proteins.

IXIFI is a medicine that affects your immune system. IXIFI can lower the ability of your immune system to fight infections.

Usual dose

IXIFI will be given to you by a healthcare professional. The medicine will be given to you through a needle placed in a vein in your arm. This is called an infusion. The infusion will take about 2 hours.

During the infusion you will be monitored for side effects. You must stay for 1 to 2 hours after the infusion so that you can continue to be watched for any reactions to the medicine.

The recommended dose of IXIFI for adults and children (6 years of age or older) is 5 mg/kg.

Infusion 1

Infusion 2

Infusion 3

Every 8 weeks thereafter for all following infusion

For adult patients who have an incomplete response, consideration may be given to adjusting the dose up to 10 mg/kg. Your doctor may consider doing a blood test (therapeutic drug monitoring) to determine how much infliximab for injection is in your blood stream in order to optimize your dose of IXIFI.

Please refer to your patient leaflet for complete dosing instructions.

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